inosine monophosphate
compound / compound-inosine-monophosphate
イノシン一リン酸
Inosine monophosphate (IMP), a umami-related substance used in hTAS2R16 cell assays.
On this page (6 sections)
Reading the bitterness
Inosine monophosphate (IMP) is one of the umami-related substances. A 2020 study used cells expressing TAS2R16, one of the human bitter taste receptors (hTAS2R16), to examine how IMP acts on this receptor's response to bitter ligands. As a result, IMP was reported to act as partial non-surmountable antagonism (response inhibition that cannot be overcome competitively) on hTAS2R16 wild-type bitter ligand response.
The full text of the same study showed a dose-response curve using salicin as a bitter agonist. When IMP was added, salicin's EC50 (half-maximal effective concentration) increased 2- to 3-fold, and at the highest concentration, IMP 30 mM, the maximum response decreased 50% compared to salicin alone. However, this result derives from an in vitro experimental system using hTAS2R16-expressing cells, and does not confirm in human sensory tests that umami substances weaken bitter taste perception.
Sources for this overview
Suppression of hTAS2R16 Signaling by Umami Substances
Checked for this overview: Adoption of qualitative findings of antagonistic action. / Adoption of numerical values for EC50 shift and maximum response decrease rate.
Follow the connections
inosine monophosphate →antagonizes→ TAS2R16
Structured claims — open a section to read each claim's confidence, evidence and limits
Mechanism and receptors (1)
Scope: The same hTAS2R16-expressing cell system
Note: Reported as partial, non-surmountable antagonism. Not extrapolated to human sensory perception.
Show data
compound-inosine-monophosphate —antagonizes→ receptor-tas2r16