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oligoporin D

compound / compound-oligoporin-d

オリゴポリンD

Oligoporin D is a triterpene glycoside bitter compound isolated from the polypore fungus Amaropostia stiptica (which has bitter taste). In heterologous expression cell assays, it activates the human bitter taste receptor TAS2R46 at extremely low threshold concentrations.

On this page (6 sections)
  1. Overview
  2. Sources for this overview (1)
  3. Topic hubs
  4. Follow the connections
  5. Related entries (10)
  6. Mechanism and receptors (2)
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Reading the bitterness

Oligoporin D is a triterpene glycoside compound isolated from Amaropostia stiptica, a polypore fungus with bitter taste. In screening using cells with heterologously expressed human bitter taste receptors (26 types), oligoporin D activated TAS2R46 at a threshold concentration of 0.1 µM and activated TAS2R46 at the lowest concentration among the bitter compounds tested. The threshold for the same compound against TAS2R1 was 30 µM, with TAS2R46 showing approximately 300-fold greater sensitivity. This is an experiment of receptor activation using heterologously expressed cells and not a measurement of sensory bitterness intensity.

In the same screening, oligoporins A, B, D, and E all activated TAS2R1 at a threshold concentration of 30 µM, whereas oligoporin F did not activate TAS2R1. For oligoporin D, in addition to activation of TAS2R1, TAS2R4, TAS2R14, and TAS2R46, activation of TAS2R41 was also confirmed, albeit more weakly. All are results at the receptor level using heterologously expressed cells and from compounds isolated from a single fungal species.

Sources for this overview

  1. Taste-Guided Isolation of Bitter Compounds from the Mushroom Amaropostia stiptica Activates a Subset of Human Bitter Taste Receptors

    Schmitz LM; Lang T; Steuer A; Koppelmann L; Di Pizio A; Arnold N; Behrens M / 2025 / journal article / full text checked

    Checked for this overview: Used the measured threshold concentration for TAS2R46 activation, which was lowest among tested compounds. / Used the pattern of oligoporins' activation of TAS2R1 and other receptors.

Follow the connections

oligoporin D →activates→ TAS2R46

oligoporin D →activates→ TAS2R1

Structured claims — open a section to read each claim's confidence, evidence and limits

Mechanism and receptors (2)

oligoporin D activates TAS2R46supported

Scope: Layer: cell. A screen using heterologous-expression cells for 26 human bitter taste receptors, with threshold concentrations measured by calcium imaging (Table 2).

Table 2: oligoporin D (3), threshold (uM): TAS2R1=30, TAS2R4=1, TAS2R14=3, TAS2R41=30, TAS2R46=0.1. Body text: "Oligoporin D (3) was found to activate TAS2R46 already at a concentration of 100 nM."
Limitations: This is a result for a compound isolated from a single mushroom species; no sensory evaluation as a food has been carried out.
Source: Taste-Guided Isolation of Bitter Compounds from the Mushroom Amaropostia stiptica Activates a Subset of Human Bitter Taste Receptors (Schmitz LM; Lang T; Steuer A; Koppelmann L; Di Pizio A; Arnold N; Behrens M, 2025) · full text checked
Show datacompound-oligoporin-d —activates→ receptor-tas2r46
claim: clm-w71g1-tas2r46-oligoporin-d-potent / type: mechanism / updated: 2026-09-07
oligoporin D activates TAS2R1supported

Scope: Layer: cell. A screen using heterologous-expression cells for 26 human bitter taste receptors, with threshold concentrations measured by calcium imaging (Table 2).

Note: Oligoporins A, B, and E are represented as the same compound group by the oligoporin-D entity (no separate entities have been created).

Table 2: threshold (uM) for TAS2R1: oligoporin A=30, oligoporin B=30, oligoporin D=30, oligoporin E=30, oligoporin F=(blank, not activated), infractopicrin=(blank). Body text: "We observed activation of receptor-transfected cells for TAS2R1, TAS2R4, TAS2R14, TAS2R46, and, more weakly though, TAS2R41" (regarding oligoporin D).
Limitations: This is a result for a compound isolated from a single mushroom species; no sensory evaluation as a food has been carried out.
Source: Taste-Guided Isolation of Bitter Compounds from the Mushroom Amaropostia stiptica Activates a Subset of Human Bitter Taste Receptors (Schmitz LM; Lang T; Steuer A; Koppelmann L; Di Pizio A; Arnold N; Behrens M, 2025) · full text checked
Show datacompound-oligoporin-d —activates→ receptor-tas2r1
claim: clm-w71g1-tas2r1-oligoporins-threshold / type: mechanism / updated: 2026-09-07

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