mouse Tas2r121
receptor / receptor-mouse-tas2r121
Tas2r121
Mouse bitter taste receptor Tas2r121. The only receptor for which a threshold concentration for theobromine was obtained in the mouse screening of Lossow 2016.
On this page (6 sections)
Reading the bitterness
In a heterologous-expression screen investigating mouse bitter taste receptors, 34 functionally expressed receptors were tested against mainly 128 naturally derived bitter compounds. For theobromine, a threshold concentration of 0.03 mM (mmol/L) was recorded only in the Tas2r121 column, and every other receptor column was a dash. However, no EC50 was given, and this is a value from a single study obtained with mouse receptors.
In the same study, phenanthroline activated Tas2r105, Tas2r121, Tas2r122, Tas2r135, and Tas2r144 at 1.0 mM, and in mouse behavioral tests it was also found aversive from the same concentration. Because 5 receptors responded, the aversion or overall bitterness cannot be attributed to Tas2r121 alone. Both are cell and behavioral results obtained in mice, and cannot be extrapolated to human receptors or human perception.
Sources for this overview
Checked for this overview: Matched the screening of 34 receptors and 128 compounds, the theobromine threshold of 0.03 mM, the dashes in the other columns, and the caveats of no EC50 and non-human receptors. / Matched phenanthroline at 1.0 mM, the 5 shared receptors, the behavioral threshold, and the inability to attribute this to a single receptor or extrapolate to humans.
Follow the connections
theobromine →activates→ mouse Tas2r121
phenanthroline →activates→ mouse Tas2r121
Structured claims — open a section to read each claim's confidence, evidence and limits
Mechanism and receptors (2)
Scope: A heterologous-expression screen of 34 mouse Tas2r receptors against 128 mostly natural bitter compounds
Note: A non-human receptor. A single study, single value; no EC50 for theobromine has been found.
Show data
compound-theobromine —activates→ receptor-mouse-tas2r121Scope: Layer: cell. A heterologous-expression screen of 34 mouse bitter taste receptors against 128 natural and synthetic bitter substances.
Show data
compound-phenanthroline —activates→ receptor-mouse-tas2r121