quercitrin
compound / compound-quercitrin
クエルシトリン / quercetin 3-O-rhamnoside
Quercitrin is a flavonoid glycoside isolated from green pepper. A corporate release reports that it activated several human bitter taste receptors on cultured cells, with high response sensitivity shown for TAS2R8.
On this page (5 sections)
Reading the bitterness
Quercitrin (quercetin 3-O-rhamnoside) is a flavonoid glycoside isolated from green pepper. A 2012 announcement by the developers, comparing a conventional cultivar with 「こどもピーマン」 (Kodomo Piman), identified one of the components found only in the conventional cultivar as quercitrin, and stated that isolated quercitrin alone is astringent. It further explains that the combination of this quercitrin astringency with the aroma of 2-isobutyl-3-methoxypyrazine was perceived as the bitterness of green pepper.
Quercitrin has also been examined in experiments on human bitter taste receptors. A joint research announcement by a company and a university, in which quercitrin was administered to cultured cells transfected with 25 human bitter taste receptors, reports that multiple receptors responded; by luminescence measurement, TAS2R8 showed the strongest response, and TAS2R38 also showed a strong response. This is not a measurement of the bitterness intensity a person experiences from eating green pepper; it is a company announcement summary, and a peer-reviewed paper, concentration-response curve, number of repetitions, and statistical values have not been confirmed.
Sources for this overview
タキイ種苗×お茶の水女子大学 共同研究成果「ピーマンの苦味成分」を解明
Checked for this overview: The 2012 announcement's description of quercitrin's isolation and astringency, and its explanation of the combination with aroma
ピーマンの苦味を感じるメカニズムの一端を解明 同時に卵黄タンパク質がピーマンの苦味を抑制する可能性も示唆
Checked for this overview: In the assay of 25 bitter taste receptors, TAS2R8 showed the strongest response
Follow the connections
quercitrin →activates→ TAS2R8
Structured claims — open a section to read each claim's confidence, evidence and limits
Mechanism and receptors (1)
Scope: Fluorescence and luminescence methods in which quercitrin was administered to cultured cells expressing human bitter taste receptors.
Note: A joint research release by a company and a university; a peer-reviewed paper has not been confirmed. Cell response is not equated with the bitterness intensity a person experiences when eating.
Show data
compound-quercitrin —activates→ receptor-tas2r8