クラリスロマイシン

"Clarithromycin (CAM), known for its severe bitterness, led to the production of commercial clarithromycin dry syrup (CAMD)... estimated to be reduced to about 1% of that of an equivalent powder suspension... nearly 99% of the bitter taste was successfully masked in the dry syrup formulation, as demonstrated not only by human gustatory sensation but also by taste sensor prediction."

"The results showed that the self-made CLM dry suspension sufficiently alleviate the bitterness of commercial CLM dry suspension (Table 4). This indicated that CLM was entrapment in the microcapsules; the bitter taste was masked efficiently in our research." "The threshold of bitterness of Self-made CLM dry suspension was determined as the point at which half of the volunteers described the taste as bitter or slightly bitter."