化合物 / compound-naringenin
ナリンゲニン
naringenin
Flavanone aglycone of naringin; released when naringinase-type enzymes hydrolyze the neohesperidose moiety
機構・受容体（1）
ナリンゲニンはhTAS2R14 and hTAS2R39 in vitro (threshold values 16 and 8 micromolar; EC50 36.2 and 32.9 micromolar)を活性化する支持あり
範囲: Heterologous cell-based receptor activation assays of a flavonoid and isoflavonoid compound set
注記: Data are for the aglycone naringenin; the glycoside naringin itself is absent from the tested compound set, and the chapter's modeling suggests glycosylation impairs hTAS2R14 activation.
Naringenin (compound 50) activated both hTAS2R14 and hTAS2R39 with threshold values 16 and 8 micromolar and EC50 values 36.2 and 32.9 micromolar; naringin (the glycoside) does not appear in the tested compound set or the known-agonist table.
限界: Assay cell line and protocol details were not re-read from the methods section; thesis chapter corresponds to Roland 2013 JAFC.
出典: Intrinsic bitterness of flavonoids and isoflavonoids and masking of their taste activity（Roland WSU, 2014） ・全文確認
文脈: Reports 68 compounds activating hTAS2R14 and 70 activating hTAS2R39 (58 overlapping) with activation thresholds spanning 0.12 to 500 micromolar; the abstract names no individual compounds.
限界: Abstract does not name naringenin; compound-level numbers come from the open-access thesis version.
出典: Bitter taste receptor activation by flavonoids and isoflavonoids: modeled structural requirements for activation of hTAS2R14 and hTAS2R39（Roland WS; van Buren L; Gruppen H; Driesse M; Gouka RJ; Smit G; Vincken JP, 2013） ・抄録確認
データを表示
compound-naringenin —activates→ "hTAS2R14 and hTAS2R39 in vitro (threshold values 16 and 8 micromolar; EC50 36.2 and 32.9 micromolar)"claim: clm-naringenin-tas2r14-39 / type: mechanism / 更新: 2026-08-30