化合物 / compound-saccharin
サッカリン
saccharin
Artificial sweetener with an aversive bitter aftertaste at higher concentrations; agonist of the TAS2R31 and TAS2R43 bitter taste receptors
関連をたどる
TAS2R31 →の苦味の個人差を媒介する→ サッカリン
機構・受容体（1）
TAS2R31はサッカリンの苦味の個人差を媒介する支持あり
範囲: Whole-gene sequencing of TAS2R30-46 in 60 Caucasian subjects, taste responses to both sweeteners, and in vitro assays of receptor alleles; 30 markers initially associated at P < 0.001
注記: クラスタ内の高 LD (D' と r2 > 0.95) のため単一 SNP 関連の大半が見かけ上という方法論的教訓つき。Hayes 2015 (src-hayes-2015-tas2r31-grapefruit) の TAS2R19 関連 = LD アーティファクト説と整合。
Thirty markers including non-synonymous variants in all five TAS2R30-46 genes were associated (P < 0.001) with responses to saccharin and acesulfame K, but linkage disequilibrium in the region was high (D prime and r2 > 0.95) and haplotype analyses revealed that most associations were spurious, arising from LD with variants in TAS2R31; in vitro assays confirmed the functional importance of four TAS2R31 mutations with independent effects on receptor response.
限界: Abstract-level: the identities of the four TAS2R31 mutations and effect sizes are in the full text, which was not retrieved. Single-ancestry sample.
出典: Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners（Roudnitzky N; Bufe B; Thalmann S; Kuhn C; Gunn HC; Xing C; Crider BP; Behrens M; Meyerhof W; Wooding SP, 2011） ・抄録確認
データを表示
receptor-tas2r31 —mediates_variation_in_bitterness_of→ compound-saccharinclaim: clm-tas2r31-saccharin-bitterness / type: mechanism / 更新: 2026-08-30