化合物 / compound-hydroxy-alpha-sanshool
hydroxy-alpha-sanshool (sanshool alkylamides)
Alkylamide associated with Zanthoxylum tingling; human psychophysics often uses the stable derivative IBA.
別名: サンショオール（ja）
主張（2）
hydroxy-alpha-sanshool (sanshool alkylamides) has_currently_proposed_mechanisms KCNK two-pore potassium channel blockade on mechanosensitive neurons, distinct from TRPV1/TRPA1 pathways支持あり
範囲: Human psychophysics using the stable sanshool derivative IBA, with supporting neurophysiology
注記: No cross-desensitization of tingle by capsaicin or mustard oil in humans.
Across experiments with 68 adults, IBA produced tingling whose desensitization and cross-desensitization profile dissociated from TRPV1/TRPA1 agonists, consistent with KCNK blockade on mechanosensitive neurons.
限界: Derivative IBA, not native sanshool; abstract-level extraction.
出典: Psychophysical Evaluation of a Sanshool Derivative (Alkylamide) and the Elucidation of Mechanisms Subserving Tingle（Albin KC; Simons CT, 2010） ・抄録確認
文脈: Tingling frequency percepts matched RA1 afferent tuning, complementing the mechanosensitive-channel account.
限界: Abstract does not name the compound; spice-level application.
出典: Food vibrations: Asian spice sets lips trembling（Hagura N; Barber H; Haggard P, 2013） ・抄録確認
hydroxy-alpha-sanshool (sanshool alkylamides) reduces tactile sensitivity during application (von Frey thresholds), unlike capsaicin支持あり
範囲: Human psychophysics using IBA on skin/lip sites
注記: Suggests tingle engages mechanosensory channels rather than purely nociceptive ones.
Tactile sensitivity was significantly reduced under IBA but not under capsaicin.
限界: Abstract-level extraction; site and magnitude not captured.
出典: Psychophysical Evaluation of a Sanshool Derivative (Alkylamide) and the Elucidation of Mechanisms Subserving Tingle（Albin KC; Simons CT, 2010） ・抄録確認